Many reasons can lead to Quickbooks wont open error. You might have damaged it the last time you used it, or your hard drive may have become corrupted, in which case the file may have become damaged. Gripes occasionally occur because old reports or transaction templates were left open and unresolved when the file was closed (especially if you selected to save the desktop after closing. Additional reasons for not being able to open the file include using the wrong version of QuickBooks, or issues with the location of the file, such as issues with access permissions, file name and extension issues, or a conflicting *QBW.tlg file.